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  • it increases the action of means that have a depressing effect on the CNS, and ethanol;
  • anxiolytics increase the intensity of the analgesic effect;
  • inductors microsomal oxidation (including barbiturates) reduces the severity and duration of the analgesic effect of the action;
  • medical products MAO inhibitors, neuroleptics - the risk of seizures (decrease seizure threshold);
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The dose for Tramadol tablets are determined by the physician individually depending on the intensity and nature of the pain. Adults and adolescents over the age of 14 years are appointed 1 suppository (100 mg). The effect of the drug is maintained for 4-8 hours. The daily dose should not exceed 400 mg. If there is pain associated with tumors patients require higher dosage of the remedy, which are available in other pharmaceutical forms. To buy Tramadol online be aware of the main overdosing symptoms as miosis, collapse, depression of the respiratory center, vomiting, convulsions, coma, and apnea. If treatment it is necessary for patients to ensure the maintenance of breathing, airway and the cardiovascular system. Opiate effects due to the overdose, are usually blocked with naloxone, and caused by higher doses of remedy seizures - benzodiazepine.

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